
A new clinical investigation published in Nutrients has confirmed that both the Mediterranean diet and a low-calorie ketogenic diet (KD) can significantly reduce blood pressure and support weight loss in individuals with elevated cardiovascular risk.
The findings suggest that dietary modification remains a powerful, non-pharmacological tool in the management of early-stage hypertension and obesity-related cardiovascular disorders.
The study, titled “The Keto–Salt Pilot Study,” directly compared the metabolic and cardiovascular effects of two popular diets in a group of overweight or obese patients diagnosed with high-normal blood pressure or grade 1 hypertension.
Key Study Highlights
- Both diets led to significant reductions in systolic and diastolic blood pressure.
- Participants on the ketogenic diet lost more weight on average, but both groups showed improved body composition.
- The Mediterranean diet group demonstrated more frequent nocturnal blood pressure dipping, an important cardiovascular health marker.
- No adverse kidney or inflammatory responses were observed in either group.
- Both diets were well-tolerated and deemed safe for short-term use under clinical supervision.
Contents
Background: Why Diet Plays a Central Role in Blood Pressure Control
According to WHO data, more than 2.5 billion people worldwide are overweight, and about 1 billion live with obesity.
This global health burden is strongly tied to elevated risks of:
- Hypertension
- Type 2 diabetes
- Dyslipidemia
- Cardiovascular disease (CVD)
Weight loss has been clinically shown to lower blood pressure, with evidence suggesting that a 5 kg weight reduction can lower systolic pressure by 4.4 mmHg and diastolic pressure by 3.6 mmHg.
The goal of the current study was to evaluate which dietary protocol—Mediterranean or ketogenic—offers better outcomes for hypertensive patients.
Read also: Diet For High Blood Pressure
Study Design and Population
The prospective pilot trial included 26 non-diabetic adults, each with:
- A BMI ≥ 27 kg/m²
- Abdominal obesity (central fat accumulation)
- High-normal BP (≥130/85 mmHg) or grade 1 hypertension (140–160/90–100 mmHg)
Participants were randomized into two groups:
- 15 subjects followed a low-calorie, high-protein ketogenic diet
- 11 subjects adopted a Mediterranean diet focused on low sodium and high potassium intake
The intervention lasted three months and was monitored through:
- Ambulatory blood pressure monitoring (ABPM)
- Bioelectrical impedance analysis (BIA)
- Standard bloodwork and safety labs
Results: Blood Pressure and Body Composition Improvements in Both Groups
Both diet groups experienced statistically significant reductions in weight and blood pressure. Here’s how the changes compared:
| Outcome | Ketogenic Diet Group | Mediterranean Diet Group |
|---|---|---|
| Baseline weight | 98.6 kg | 93.8 kg |
| Final weight | 87.3 kg | 86.0 kg |
| Mean systolic BP drop | 9 mmHg | 9 mmHg |
| Mean diastolic BP drop | ~5.3 mmHg | ~5.3 mmHg |
| Nocturnal BP dipping | Less frequent | More frequent |
Interpretation: Metabolic Gains Are Comparable, Cardiovascular Markers Differ
While both diets achieved comparable blood pressure reductions, the Mediterranean diet showed advantages in nighttime BP modulation, a subtle but clinically meaningful marker linked to lower cardiovascular mortality.
Additionally, the ketogenic diet achieved more aggressive short-term weight loss, likely due to carbohydrate restriction and metabolic adaptation.
Researchers emphasize that no inflammatory markers or signs of renal stress were found in either group, underscoring the short-term safety of both interventions under medical supervision.
Read also: Impact Of Eating (or Not Eating) On Your Blood Pressure
Clinical Takeaway: Personalized Nutrition Still Reigns
According to the study authors, both diets are:
- Effective in reducing hypertension markers
- Safe when properly guided by healthcare professionals
- Capable of improving metabolic profiles and body composition
However, long-term adherence, individual tolerance, and underlying health risks must be considered.
The authors call for larger-scale, long-term studies to confirm these outcomes and define diet-specific guidelines for hypertension management.




