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Home » EMT

What is Sepsis Anyway?

Steve Whitehead

Steve Whitehead | Saving Lives, Sharing Wisdom: EMT Insights
Last update: November 10, 2022

sepsis

Don’t feel bad if you don’t have a really good answer. Most of us don’t. Before I started researching the question two years ago, I didn’t have much of an answer either. People get sick. Some get better. Some get worse. If they get really sick they transition into septic shock. End of story.

As an EMS educator, I didn’t go into too much more detail than that, so my own lack of knowledge was carried forward by my EMT students and the cycle continued. Sure, I could turn around and blame my instructor, but here’s a better idea, let’s end the cycle right now.

Here is your one stop shopping guide to the pathophysiology of sepsis. Give me a few minutes of your time and I’ll give you a more complete understanding of the etiology that we call sepsis than most of the prehospital folks you’re working alongside. Put your thinking cap on. Here is sepsis in a nutshell.

In this article hide
1. The Sepsis Progression
1.1. 1) The Source of Infection
1.2. 2) Pro and Anti-Inflammatory Mediators in Balance
1.3. 3) The Pro-Inflammatory Surge
1.4. 4) Endothelial Damage and Impaired Fibrinolysis (Vessels Leak and Blood Clots)
1.5. 5) End Organ Hypoxia and Failure

The Sepsis Progression

1) The Source of Infection

It all begins with an exogenous pathogen. There’s got to be one. Some outside bad thing, be it viral, bacterial, fungal or parasitic, finds its way into our bodies and takes up residence. And more often than not, you can identify it. Either by digging in for more information about the presenting symptoms or asking questions about high risk possibilities.

The source of infection could be a wound, a recent surgical procedure or an exposure to someone with a known infection. Or it could be an exacerbation of any of the run of the mill infection that we humans commonly get. From pneumonia to bladder infections, any common infection can advance from a localized minor complaint to a systemic inflammatory response.

2) Pro and Anti-Inflammatory Mediators in Balance

In response to that pathogen, our bodies wage a complex war against the outside invaders. Pro-inflammatory mediators like braykin, C3 and C5 from the component system and histamine cause local tissue inflammation. This causes damage to the endothelial walls of the vasculature. Vessels leak fluid into the intercellular space.

At this stage, it’s important to keep in mind that all of this is actually a good thing. Leaky vessels help to spread erythrocytes to the source of infection. Inflammation is the first stage of tissue healing. All is right with the inner world.

3) The Pro-Inflammatory Surge

This is where things start to go awry. Here at the tipping point between uncomplicated infection and sepsis, the balance between pro-inflammatory and anti-inflammatory mediators shifts. Anti-inflammatory mediators become overwhelmed The body begins producing more pro-inflammatory mediators and the ones already in circulation overstay there welcome.

At this point, what was a localized inflammatory attack becomes a full, system-wide inflammation party. All of those things that are helpful at a local level become problematic when pro-inflammatory mediators increase at an unchecked rate. The result is known as SIRS. (Systemic Inflammatory Response Syndrome.)

4) Endothelial Damage and Impaired Fibrinolysis (Vessels Leak and Blood Clots)

With unmediated inflammation running the show, a bunch of bad stuff happens. The top two problems on the list are endothelial damage and impaired fibrinolysis.

  • Endothelial Damage – Recall that those pro-inflammatory mediators weren’t very gentle with the vessel walls. They roll along tearing up the cells lining the vessel wall and allowing fluid to leak from the vessel. As this happens system-wide, large volumes of vascular fluid leaks into the intercellular space. This leads to a distributive shock state. Without enough circulating blood volume the body transitions into a state of shock.
  • Impaired Fibrinolysis – Chemical imbalances initiated by the pro-inflammatory surge disrupt the normal clotting cascade. This causes the blood remaining in the vasculature to clot. Blood clots clog the micro-vasculature necessary to deliver oxygen to vital organs. Systemic clotting is the second punch in the one-two combination of septic shock.

5) End Organ Hypoxia and Failure

The deadly combination of big blood vessels leaking and small blood vessels clotting combine to cut off the oxygen supply to every organ in the body. This end organ hypoxia effects every major system in the body. Liver and kidneys fail, lungs lose function, cardiac muscle weakens, blood vessels dilate, and even basic functions like digestion and temperature regulation ultimately fail. This phase is sometimes referred to as MODS or multiple organ dysfunction syndrome.

These signs of end organ failure are what we typically associate with septic shock. The real challenge in sepsis is identifying the septic progression before it reaches the severe sepsis phase. Once system wide inflammation, vessel leakage and clotting are underway, mortality rates can exceed fifty percent. Much like hypovolemic shock, time is a critical factor in saving lives.

While EMS is accustomed to racing off to trauma centers with patients who are at risk for hypovolemia, our response to sepsis presentations are often a bit more hum-drum. Hopefully, with your new understanding of the sepsis progression, you’ll be more prepared to identify your next septic patient and respond.

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Steve Whitehead

About Steve Whitehead

I am a firefighter paramedic for the South Metro Fire Rescue Authority and freelance writer. I have been writing for EMS journals for over five years now and have found the experience both rewarding and challenging. I’ve had the good fortune to see my articles on the cover of EMS Magazine, Advanced Rescue Technology and JEMS.

Disclaimer: This article is republished from the archives of this website. Articles you may find in the EMT category are authored by Steve Whitehead. If you find his articles interesting and want to read more of them, check EMS1.com.

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